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Alpha-gal syndrome: What to know about tick-borne illness

Beyond the well-documented threat of Lyme disease, health officials are now highlighting a lesser-known but potentially life-threatening consequence of tick bites: a severe allergy to meat.
This condition, termed alpha-gal syndrome, was first identified about 15 years ago, linked to a particular tick species.
Cases are on the rise, with sufferers reporting symptoms like hives, diarrhea, and itchiness after consuming even a mouthful of meat, and sometimes dairy. Notably, the allergy does not affect seafood or poultry; chicken, turkey, and eggs are safe to eat.
Historically, treatment has centered on avoiding beef, pork, and lamb, and carrying an epinephrine injector for emergencies. Yet, a significant development has emerged, with regulators recently approving the first drug for the condition, and more therapies expected to follow.
Here’s what to know about alpha-gal syndrome:
Unlike other tick-borne illnesses, such as Rocky Mountain spotted fever, alpha-gal syndrome isn’t caused by a bacteria or a virus. Instead, it occurs when the human immune system triggers an allergic response to a type of sugar, known as alpha-gal.
Alpha-gal is found in the meat of most mammals, but not in humans or other primates. It’s also found in the saliva of certain ticks.
When eaten, the sugar is normally harmless. But when ticks bite through the skin, they can introduce the sugar directly into the bloodstream. That triggers the development of antibodies — immune system proteins that fight off foreign invaders — that quickly learn to identify and attack alpha-gal sugar molecules.
“It turns out that the skin is a fantastic way to make an allergic response,” said Dr. Scott Commins, an alpha-gal syndrome researcher at the University of North Carolina. “If this all happened orally, and we were eating alpha-gal like we do with steaks or barbecue, then we wouldn’t become allergic.”
People that develop the antibodies will often experience a strong allergic reaction a few hours after consuming meat or dairy. But it can take weeks or months for the problem to develop, with the severity of symptoms often increasing over time.
Experts point to increased awareness among health professionals and the public.
“I think part of it is more people have learned about it and are on the watch for this syndrome,” said Maria Diuk-Wasser, a Columbia University researcher who studies tick-borne diseases.
But rising cases also reflect the expanding habitat range of the lone star tick, the primary source of the condition in the U.S. Often identifiable by a white dot on its back, the lone star tick is most common in the eastern and southern U.S. But in recent years it’s been reported in new parts of the country, including the Great Lakes region and as far north as Martha’s Vineyard in Massachusetts.
Researchers worry that other types of ticks, including blacklegged ticks, may also increasingly spread the condition.
Roughly 450,000 Americans are estimated to have developed the allergy, according to a 2023 study by the the Centers for Disease Control and Prevention.
People usually seek medical attention after experiencing worrisome symptoms, including hives, dizziness, difficulty breathing and swelling of the lips, throat, tongue or eyelids. Some people may only experience digestive issues, including diarrhea, stomach pain, vomiting and nausea.
Doctors diagnose the allergy based on results from a blood test, symptoms and other details reported by the patient, including whether they recall any recent bug bites.
The blood test detects the presence of alpha-gal antibodies, but not all patients with a positive result develop the condition. Sometimes the test can also be wrong.
“The blood test in and of itself is great, but you can’t rely on that just for diagnosis. You need the actual symptoms too,” Commins said. “In the allergy world, we have a lot of trouble with false positives on blood tests.”
Doctors generally advise patients to avoid beef, pork, lamb and other meats from mammals. Some people are still be able to consume dairy products from these animals, including milk, cheese and butter. Those with particularly severe reactions may need to avoid foods made with other animal byproducts such as gelatin, which is found in marshmallows and gummy bears.
One rare exception: meat from a small number of pigs that have been genetically modified to not produce alpha-gal. Approved for consumption by the Food and Drug Administration in 2020, the pigs are bred as part of an experimental effort to harvest animal organs for transplantation into humans. Deactivating the alpha-gal gene was a critical first step to make sure the human immune system wouldn’t immediately reject the foreign organs. Meat from these so-called “GalSafe” pigs is available from a company called Amaroo Hills.
People with the syndrome may also have to avoid certain medical products and implants. For instance, many heart valves are made from cow or pig parts.
The allergy can fade away in some people after several years. Commins has seen that happen in about 15% to 20% of his patients. But it’s critical to avoid new tick bites.
In 2024, the FDA approved an injectable drug called Xolair for a variety of food allergies, including alpha-gal syndrome. The drug doesn’t reverse the condition but helps reduce severe allergic reactions after accidental exposure to meat.
The drug was first approved more than 20 years ago for patients with hard-to-control asthma. It works by reducing the release of biological chemicals that cause inflammation and other allergic reactions.
Commins and other researchers hope to study other previously approved drugs as new options for patients.
“There are certain (biologic drugs) out there nowadays that interfere with the allergic signaling,” Commins said. “We think that if you were on one of those — or if you got one quickly enough after a tick bite — perhaps it could interfere with the entire allergic response process.”

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Ebola one month on: will the latest outbreak in DRC become the most deadly yet?

When an orphanage in Bunia took in a newborn baby after his mother died from Ebola, the nuns who ran it hoped they were giving the infant a chance for life. The baby survived for only another two weeks. Now four of the nuns who cared for him have fallen sick with the deadly virus.
It is a snapshot of the tragedies at the centre of an outbreak in which the number of victims is roughly doubling every week, according to the World Health Organization (WHO).
“It’s really, really devastating,” says Dr Babou Rukengeza, Save the Children’s Ebola response lead in the Democratic Republic of the Congo (DRC). All the children and staff at the orphanage are now being monitored for symptoms.
A month on since the latest outbreak of Ebola, caused by the Bundibugyo virus, was first identified in the DRC, the latest figures from the UN show 676 confirmed cases and 136 deaths, the overwhelming majority in the DRC’s Ituri province.
Frontline workers say they are still battling shortages of the necessary supplies, including personal protective equipment and vehicles to transport dead bodies. Testing has improved, they say, but still needs to be done faster and carried out nearer to patients.
In neighbouring Uganda, which has reported 19 cases and two deaths, intensive tracing of contacts means the outbreak is under control, health officials say.
Despite the global risk remaining low, 22 countries, including the US, have imposed travel restrictions on people coming from the DRC, Uganda or South Sudan, according to Africa CDC, the health agency of the African Union.
Those restrictions have been criticised as impeding health agencies’ response. What the DRC really needs from the international community, experts say, is flexible funding that it can use to get the situation under control.
There are reasons for hope: scientists are working rapidly to test and produce vaccines against Bundibugyo, and the latest research suggests existing antivirals are likely to be helpful.
In Ituri, the organisations involved in the response meet daily to coordinate plans, and African leaders will meet virtually on Tuesday to discuss the outbreak and make funding commitments.
But there are also strong headwinds that are slowing the response: conflict continues in the worst-hit areas and misinformation is rife, leading people to avoid hospitals and the care that could save their lives, and there have even been attacks on aid workers and treatment centres.
Gratien Iracan, the local MP for the provincial capital, Bunia, noted on social media last week: “Despite the millions of dollars announced by the international community to support the response to Ebola, these resources are not yet sufficiently visible on the ground in Ituri.”
In subsequent posts, he highlighted a doctor’s death from Ebola, saying the medic had sent messages from his hospital bed complaining of poor care in the clinic. The Guardian has not been able to verify those messages.
Iracan also described an incident in which a community had called the authorities to report a suspected case of Ebola but the promised support had not arrived, sparking “incomprehension, anger and concern”.
According to Africa CDC, community trust is “a critical challenge” – CNN video footage from Bunia’s central market shows people denying the virus exists and blaming Red Cross workers for spreading it.
In a statement, the continental health watchdog cited “reports of resistance to hygiene measures and decontamination in some communities, as well as incidents of mob violence”.
A key reason for this stems from people’s reluctance to allow their sick relatives to be cared for by strangers in healthcare isolation units – and the importance of funeral rites.
For some people, their fear of displeasing God over not performing an appropriate burial for a relative can be greater than their fear of contracting a virus. According to one study after the 2016 outbreak, exposure to body fluids during each “unsafe” funeral for Ebola victims created an average of 2.58 secondary cases.
Informing people about the symptoms and risks – using mass media such as radio and TV as well as face-to-face contact in the community – has become a key part of work on the ground, says Rukengeza.
“We are pushing and currently we are working with the leaders, community leaders, religious and other people here on the ground just to let them know that this is really Ebola virus, and they have to pay attention,” he says.
With about 600 confirmed cases in one area, health experts would expect to have about 24,000 contacts to monitor. On Thursday, Dr Jean Kaseya, director general of Africa CDC, says there are 4,955 listed – and 57% of those are being monitored.
“It means there is a huge risk of transmission [being] sustained in the community,” Kaseya says. “We still have some confirmed cases not admitted [to hospital]. They are somewhere in the community, elsewhere.”
A joint response plan drawn up by Africa CDC and the WHO estimates that $518m (£387m) will be needed over the next six months to bring the outbreak under control. Kaseya says some early financial pledges from around the world “were not real”, but he now thinks that about $212m, including support in kind, was “almost there”.
Many of those infected are healthcare workers. Ebola is spread via body fluids, and those caring for the sick are most likely to be exposed to them.
Speaking from Bunia on Thursday, Dr Salim Abdool Karim, an epidemiologist who chairs the Africa CDC emergency consultative group, says he visited a treatment centre that day: “There were 22 patients in that particular hospital, five of whom were healthcare workers, two doctors and an anaesthetist.”
Even before Ebola arrived, Ituri faced a humanitarian crisis, with tens of thousands of people displaced by years of conflict. WHO officials have registered more than 520 security incidents affecting their teams in the field so far.
Over the past month, the outbreak has been gradually moving up the grim league tables that rank Ebola epidemics by case numbers and death toll. It is now the third largest on record. Modelling by the US Centers for Disease Control and Prevention suggests this outbreak could grow to match the 2014-16 one in west Africa, which killed more than 11,000 people.
“We hope we can stop that,” says Kaseya, “and it won’t move from the third to the second, even the first one.”

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2 daylight raccoon attacks within hours have New Jersey town eyeing rabies pellets

Ridgewood, New Jersey, is dealing with the fallout from two raccoon bites reported hours apart. The incidents sent a child and an adult for preventive rabies care and led officials to weigh an uncommon tactic: distributing oral vaccine bait for wild animals.
What happened?
WABC reported that one victim was an adult bitten on private property, after a 7-year-old boy had been attacked around 7 p.m. the day before near Maple Field & Community Garden and bitten on the upper leg.
WABC said the cases were reported close together in time, fueling concern that a raccoon in the area could be sick or acting abnormally. Both people received rabies treatment as a precaution.
So far, Animal Control officers searching the area have not found evidence of the raccoon. Residents are being asked to contact the Ridgewood Police Department if they see an animal that appears sick, injured, or unusually aggressive.
Why does it matter?
Rabies is rare in humans in the United States, but once symptoms appear, it is almost always fatal. Any bite from a potentially infected wild animal is a serious public health concern, particularly in places where children and pets may be nearby.
The attacks also underscore how closely people and wildlife overlap in many suburban communities. Raccoons are highly adaptable and often linger near gardens, yards, pet food, trash, and other human-created food sources, increasing the chances of bold or risky encounters.
As neighborhoods continue to expand into wooded areas and animals learn to associate people with easy meals, these encounters can become more common. When wild animals lose their fear of humans, the risks rise on both sides — people can be hurt, and the animal may ultimately need to be trapped or euthanized.
What’s being done?
One option now under discussion in Ridgewood is placing rabies vaccination pellets in wooded areas where animals gather, WABC reported. The flavored bait is meant to be eaten by wildlife, and federal agencies have used it for years to help curb the spread of rabies.
Officials say federal agencies do not consider the pellets dangerous to other animals, making the approach a practical way to reduce risk without trying to remove every raccoon from the area.
If you spot an animal acting strangely, report it rather than confront it. Preventing contact is the safest move for people, pets, and wildlife alike, and small changes at home can help reduce the chances of future encounters.
In communities where backyards, parks, and wooded habitats exist side by side, even a routine outing can quickly become a public health concern.

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What is alpha-gal syndrome?

WASHINGTON (AP) — It’s common knowledge that ticks can spread infections that cause serious illnesses, including Lyme disease. Now health officials are trying to raise awareness of a lesser-known problem: a life-threatening allergy to meat triggered by tick bites.
The problem, known as alpha-gal syndrome, was first linked to a particular species of ticks about 15 years ago. But cases are on the rise as more people report symptoms such as hives, diarrhea and itchiness after eating as little as a mouthful of meat and — in some cases — dairy. The allergy doesn’t impact consumption of seafood or poultry. Chicken, turkey and eggs are all OK to eat.
For years, the standard treatment has involved avoiding foods that come from cows, pigs and lambs while carrying an epinephrine injector in case of medical emergency. But regulators recently approved the first drug for the condition, and more therapies may be on the way.
Here’s what to know about alpha-gal syndrome:
What causes it?
Unlike other tick-borne illnesses, such as Rocky Mountain spotted fever, alpha-gal syndrome isn’t caused by a bacteria or a virus. Instead, it occurs when the human immune system triggers an allergic response to a type of sugar, known as alpha-gal.
Alpha-gal is found in the meat of most mammals, but not in humans or other primates. It’s also found in the saliva of certain ticks.
When eaten, the sugar is normally harmless. But when ticks bite through the skin, they can introduce the sugar directly into the bloodstream. That triggers the development of antibodies — immune system proteins that fight off foreign invaders — that quickly learn to identify and attack alpha-gal sugar molecules.
“It turns out that the skin is a fantastic way to make an allergic response,” said Dr. Scott Commins, an alpha-gal syndrome researcher at the University of North Carolina. “If this all happened orally, and we were eating alpha-gal like we do with steaks or barbecue, then we wouldn’t become allergic.”
People that develop the antibodies will often experience a strong allergic reaction a few hours after consuming meat or dairy. But it can take weeks or months for the problem to develop, with the severity of symptoms often increasing over time.
Why are more people being diagnosed with alpha-gal syndrome?
Experts point to increased awareness among health professionals and the public.
“I think part of it is more people have learned about it and are on the watch for this syndrome,” said Maria Diuk-Wasser, a Columbia University researcher who studies tick-borne diseases.
But rising cases also reflect the expanding habitat range of the lone star tick, the primary source of the condition in the U.S. Often identifiable by a white dot on its back, the lone star tick is most common in the eastern and southern U.S. But in recent years it’s been reported in new parts of the country, including the Great Lakes region and as far north as Martha’s Vineyard in Massachusetts.
Researchers worry that other types of ticks, including blacklegged ticks, may also increasingly spread the condition.
Roughly 450,000 Americans are estimated to have developed the allergy, according to a 2023 study by the the Centers for Disease Control and Prevention.
When should someone get tested?
People usually seek medical attention after experiencing worrisome symptoms, including hives, dizziness, difficulty breathing and swelling of the lips, throat, tongue or eyelids. Some people may only experience digestive issues, including diarrhea, stomach pain, vomiting and nausea.
Doctors diagnose the allergy based on results from a blood test, symptoms and other details reported by the patient, including whether they recall any recent bug bites.
The blood test detects the presence of alpha-gal antibodies, but not all patients with a positive result develop the condition. Sometimes the test can also be wrong.
“The blood test in and of itself is great, but you can’t rely on that just for diagnosis. You need the actual symptoms too,” Commins said. “In the allergy world, we have a lot of trouble with false positives on blood tests.”
Which foods are off limits?
Doctors generally advise patients to avoid beef, pork, lamb and other meats from mammals. Some people are still be able to consume dairy products from these animals, including milk, cheese and butter. Those with particularly severe reactions may need to avoid foods made with other animal byproducts such as gelatin, which is found in marshmallows and gummy bears.
One rare exception: meat from a small number of pigs that have been genetically modified to not produce alpha-gal. Approved for consumption by the Food and Drug Administration in 2020, the pigs are bred as part of an experimental effort to harvest animal organs for transplantation into humans. Deactivating the alpha-gal gene was a critical first step to make sure the human immune system wouldn’t immediately reject the foreign organs. Meat from these so-called “GalSafe” pigs is available from a company called Amaroo Hills.
People with the syndrome may also have to avoid certain medical products and implants. For instance, many heart valves are made from cow or pig parts.
How long does it last?
The allergy can fade away in some people after several years. Commins has seen that happen in about 15% to 20% of his patients. But it’s critical to avoid new tick bites.
What treatments are available?
In 2024, the FDA approved an injectable drug called Xolair for a variety of food allergies, including alpha-gal syndrome. The drug doesn’t reverse the condition but helps reduce severe allergic reactions after accidental exposure to meat.
The drug was first approved more than 20 years ago for patients with hard-to-control asthma. It works by reducing the release of biological chemicals that cause inflammation and other allergic reactions.
Commins and other researchers hope to study other previously approved drugs as new options for patients.
“There are certain (biologic drugs) out there nowadays that interfere with the allergic signaling,” Commins said. “We think that if you were on one of those — or if you got one quickly enough after a tick bite — perhaps it could interfere with the entire allergic response process.”
___
Associated Press video journalist Mary Conlon contributed to this story.
___
The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group and the Robert Wood Johnson Foundation. The AP is solely responsible for all content.

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445 birds euthanized due to bird flu outbreak at Rhode Island market

The Rhode Island Department of Health and Rhode Island Department of Environmental Management said that 445 birds at a bird market in Providence were euthanized after the detection of avian flu during routine quarterly testing.
The department said that the asymptomatic birds were located at Antonelli Poultry.
The business must also remain closed until five days after the birds were disposed of and the entire business was cleaned and sanitized.
“Because staff at Antonelli Poultry may have been exposed to avian influenza, and out of an abundance of caution, RIDOH is monitoring all staff for 10 days for symptoms of avian influenza,” a release said.
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To prevent any foodborne illness, RIDOH recommended:
Wash hands, utensils, and cutting boards before and after contact with raw poultry, meat, seafood, and eggs.
Keep raw poultry and meat away from food that won’t be cooked—like fruits and vegetables.
Cook food to the proper temperature and use a food thermometer to check the food’s internal temperature. You cannot tell by looking at food if it is cooked to the proper temperature.
The following recommendations were also given to avoid avian flu:
Avoid direct contact with birds or other animals infected with, or suspected to be infected with, avian influenza.
Avoid direct contact with sick or dead wild birds, poultry, or other animals.
Do not touch surfaces or materials contaminated with saliva, mucous, or animal feces from wild or domestic birds or other animals with confirmed or suspected avian influenza.
Do not touch or drink raw milk (unpasteurized milk), especially from animals with confirmed or suspected avian influenza.
Do not handle any sick or dead wild birds or other animals without wearing personal protective equipment (PPE).
More information on avian flu in humans can be found here.

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NEW: Avian Flu Confirmed at Antonelli Poultry in…

NEW: Avian Flu Confirmed at Antonelli Poultry in Providence, 445 Birds Euthanized
The Rhode Island Department of Health (RIDOH) and the Rhode Island Department of Environmental Management (DEM) want to alert consumers that birds at Antonelli Poultry in Providence tested positive for the H5N1 strain of avian influenza during routine quarterly testing by the US Department of Agriculture (USDA).
The infected birds, which included live chickens and ducks, did not come from Rhode Island farms. They were from out-of-state dealers.
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On Saturday, the State Veterinarian oversaw the USDA-required humane euthanasia of about 445 asymptomatic birds at the market to prevent the spread of the disease to other birds. Per USDA regulations, Antonelli Poultry will be closed until 5 days after they have disposed of infected birds and have cleaned and sanitized all areas of the business. Antonelli Poultry is closely cooperating with DEM and RIDOH.
Staff Monitored for 10 Days
Because staff at Antonelli Poultry may have been exposed to avian influenza, and out of an abundance of caution, RIDOH is monitoring all staff for 10 days for symptoms of avian influenza. The overall risk of humans getting H5N1 remains low.
“Cooking poultry to the proper internal temperature of 165° kills bacteria and viruses, including avian influenza A viruses,” says Director of Health Jerry Larkin, MD. “RIDOH recommends that if anyone still has poultry they bought between June 9 and June 12 that was killed and dressed by Antonelli Poultry, they should double bag the poultry and dispose of it in their regular trash. If you have properly cooked and eaten chicken from Antonelli Poultry, the risk of becoming ill is very low; however, if you develop symptoms of avian influenza, you should seek medical care.”
Symptoms of avian influenza include eye redness, fever, cough, sore throat, runny nose, muscle or body aches, fatigue, shortness of breath or difficulty breathing, or pneumonia that requires hospitalization. People who get avian influenza can be treated with antivirals.
To prevent any foodborne illness, RIDOH recommends:
Wash hands, utensils, and cutting boards before and after contact with raw poultry, meat, seafood, and eggs.
Keep raw poultry and meat away from food that won’t be cooked—like fruits and vegetables.
Cook food to the proper temperature and use a food thermometer to check the food’s internal temperature. You cannot tell by looking at food if it is cooked to the proper temperature.
Avian influenza infections in humans are rare. The best way to prevent avian influenza in humans is for people to avoid exposure.
Avoid direct contact with birds or other animals infected with, or suspected to be infected with, avian influenza.
Avoid direct contact with sick or dead wild birds, poultry, or other animals.
Do not touch surfaces or materials contaminated with saliva, mucous, or animal feces from wild or domestic birds or other animals with confirmed or suspected avian influenza.
Do not touch or drink raw milk (unpasteurized milk), especially from animals with confirmed or suspected avian influenza
Do not handle any sick or dead wild birds or other animals without wearing personal protective equipment (PPE).
“DEM works closely with federal and State veterinary and public health officials to respond quickly to confirmed H5N1 cases in domestic birds,” said State Veterinarian Scott Marshall, DVM. “The USDA performs quarterly testing at live bird markets to ensure the public’s safety.”
This is Rhode Island’s first confirmed domestic bird case of avian influenza in 2026. Rhode Island has previously confirmed infections in noncommercial flocks in 2022 and in 2025.
To learn more about avian influenza in humans, visit RIDOH’s website. To learn more about avian influenza in animals, visit DEM’s website.

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